1) Single dose aspirin 1000 mg + 10 mg Metoclopramide
- Effective in more than half of the patient.
- Aspirin reduced associated symptoms of nausea, vomiting, photophobia, and phonophobia
- More superior to sumatriptan 50 mg for 2 hours pain relief and pain free.
2) Sumatriptan 100 mg
- Superior to aspirin plus Metoclopramide for 2 h pain free.
Ref: Emma Hitt, " Single Dose of Aspirin Effective in Relieving Migraine Pain", http://cme.medscape.com/viewarticle/720439?src=cmenews&uac=113567PT
3) 500mL NS + IV stemetil 10 mg + IV promethazine 12.5 mg
- IV prochlorperazine with diphenhydramine is superior to subcutaneous sumatriptan in the treatment of migraine.
Ref: http://drcd2009.wordpress.com/2010/01/07/579/, based on study by Kostic MA, Gutierrez FJ, Rieg TS, Moore TS, Gendron RT. Emerg Med. 2009 Dec 31, “A Prospective, Randomized Trial of Intravenous Prochlorperazine versus Subcutaneous Sumatriptan in Acute Migraine Therapy in the Emergency Department"
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